出生年月：1961.10
学历与职称：所长、教授、博士生导师
专业方向：有机化学
电话：027-68755925
Email：xumu@whu.edu.cn
教育与研究经历
1978-1982 武汉大学学士;
1982-1985 中国科学院福建物质结构研究所硕士;
1985-1987 加利福尼亚州立大学圣地亚哥分校硕士;
1987-1992 斯坦福大学博士;
1992-1994 斯坦福大学博士后;
1994-2006 美国宾夕法尼亚州州立大学教授;
2007- 美国新泽西州立罗格斯大学杰出教授;
2005- 武汉大学长江学者讲座教授;
2008- 武汉大学“高等学校学科创新引智计划”学术大师;
2005- 武汉大学化学与分子科学学院绿色催化研究所所长;
2011- 武汉大学国家“千人计划”特聘专家。
研究领域与兴趣
1、发展高效、高选择性不对称催化反应手性配体工具箱;
2、发展高效、高选择性的化学催化反应(不对称氢化、不对称氢甲酰化、线性氢甲酰化、酯基以及酰胺类化合物的绿色还原等);
3、催化反应在重要的药物中间体和生物活性天然产物合成中的应用。
武汉大学绿色催化研究所招聘信息
招聘对象：
A. 以张绪穆老师领导的青年“千人”(教授)，独立研究方向
B. 张绪穆实验小组的副教授(工作助手)
C. 张绪穆实验小组的博士后(国内工作一段时间后可推荐至国外知名院校继续博士后研究工作)
D. 有致力于绿色催化研究的博士生
教学情况
承担项目与课题
学术兼职
代表性成果
1. Catalytic Enantioselective Desymmetrization of Meso Cyclic Anhydrides via Iridium-Catalyzed Hydrogenation. Liu, T. L.; Li, W.; Geng, H. L.; Wang, C. J.; Zhang, X. M. Organic Letters. 2013, 15, 1740.
2. Rhodium-Catalyzed Asymmetric Hydroformylation of 1,1-Disubstituted Allylphthalimides: A Catalytic Route to β3-Amino Acids. Zheng, X.; Cao, B. N.; Liu, T. L.; Zhang, X. M. Advanced Synthesis & Catalysis. 2013, 355, 679.
3. Cascade Synthesis of Fenpiprane and Related Pharmaceuticals via Rhodium-Catalyzed Hydroaminomethylation. Li, S. K.; Huang, K. X.; Zhang, J. W.; Wu, W. J.; Zhang, X. M. Organic Letters. 2013, 15, 1036.
4. A Novel Triphosphoramidite Ligand for Highly Regioselective Linear Hydroformylation of Terminal and Internal Olefins Chen, C. Y.; Qiao, Y.; Geng, H. L.; Zhang, X. M. Organic Letters. 2013, 15, 1048.
5. Rhodium-Catalyzed Enantioselective Hydrogenation of Oxime Acetates.Huang, K. X.; Li, S. K.; Chang, M. X.; Zhang, X. M. Organic Letters. 2013, 15, 484.
6. Highly enantioselective hydrogenation of β,β-disubstituted nitroalkenes. Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu. Angew. Chem. Int. Edit. 2012, 51, 10679. DOI: 10.1002/anie.201202715
7. New tetraphosphorus ligands for highly linear selective hydroformylation of allyl and vinyl derivatives. Cai, Chaoxian; Yu, Shichao; Cao, Bonan; Zhang, Xumu. Chem. Eur. J. 2012, 18, DOI: 10.1002/chem.201201396.
8. Access to both enantiomers of α-chloro-β-keto esters with a single chiral ligand: highly efficient enantioselective chlorination of cyclic β-keto esters catalyzed by chiral copper(II) and zinc(II) complexes of a spiro-2,2'-bischroman-based bisoxazoline ligand. Li, Jie; Pan, Wei; Wang, Zheng; Zhang, Xumu; Ding, Kuiling. Adv. Synth. Catal. 2012, 354, 1980.
9. Highly enantioselective hydrogenation of β-ketoenamides with the Rh-ZhangPhos catalyst. Huang, Kexuan; Zhang, Xiaowei; Geng, Huiling; Li, Sheng-kun; Zhang, Xumu. ACS Catalysis 2012, 2, 1343.
10. Highly regioselective isomerization-hydroaminomethylation of internal olefins catalyzed by Rh complex with Tetrabi-type phosphorus ligands. Liu, Guodu; Huang, Kexuan; Cao, Bonan; Chang, Mingxin; Li, Shengkun; Yu, Shichao; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Org. Lett. 2012, 14, 102.
11. Highly regioselective hydroaminomethylation of terminal olefins to linear amines using Rh complexes with a Tetrabi phosphorus ligand. Liu, Guodu; Huang, Kexuan; Cai, Chaoxian; Cao, Bonan; Chang, Mingxin; Wu, Wenjun; Zhang, Xumu. Chem. Eur. J. 2011, 17, 14559.
12. Ruthenium-catalyzed asymmetric hydrogenation of β-keto enamines: an efficient approach to chiral γ-amino alcohols. Geng, Huiling; Zhang, Xiaowei; Chang, Mingxin; Zhou, Le; Wu, Wenjun; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 3039.
13. Highly regioselective isomerization-hydroformylation of internal olefins catalyzed by Rhodium/tetraphosphine complexes. Cai, Chaoxian; Yu, Shichao; Liu, Guodu; Zhang, Xiaowei; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 2665.
14. A highly efficient and enantioselective access to tetrahydroisoquinoline alkaloids: asymmetric hydrogenation with an Iridium catalyst. Chang, Mingxin; Li, Wei; Zhang, Xumu. Angew. Chem. Int. Edit. 2011, 50, 10679.
15. Spiro-2,2'-bichroman-based bisoxazoline (SPANbox) ligands for Zn(II)-catalyzed enantioselective hydroxylation of β-keto esters and 1,3-diester. Li, Jie; Chen, Gang; Wang, Zheng; Zhang, Ruzhou; Zhang, Xumu; Ding, Kuiling. Chem. Sci. 2011, 2, 1141.
16. New synthetic strategy for high-enantiopurity N-protected α-amino ketones and their derivatives by asymmetric hydrogenation. Sun, Tian; Hou, Guohua; Ma, Miaofeng; Zhang, Xumu. Adv. Synth. Catal. 2011, 353, 253.
17. Enantioselective synthesis of optically pure β-amino ketones and γ -aryl amines by Rh-catalyzed asymmetric hydrogenation. Geng, Huiling; Huang, Kexuan; Sun, Tian; Li, Wei; Zhang, Xiaowei; Zhou, Le; Wu, Wenjun; Zhang, Xumu. J. Org. Chem. 2011, 76, 332.
18. Synthesis of enamides via Cu(I)-catalyzed reductive acylation of ketoximes with NaHSO3. Guan, Zheng-Hui; Zhang, Zhi-Yuan; Ren, Zhi-Hui; Wang, Yao-Yu; Zhang, Xumu. J. Org. Chem. 2011, 76, 339.
发明专利：
1. “New Chiral Ferrocene Phosphines and Their Applications for Asymmetric Catalytic Reactions” X. Zhang, US patent 09/781,083, filed February 9, 2001 and PCT/US01/044.
2. "3,3'-Substituted Chiral Biaryl Phosphines and Phosphintes for Asymmetric Catalytic Reactions ” X. Zhang, U. S. Patent, filed November 16, 2001 and PCT Application.
3. "New Transition Metal Catalyzed Reactions” A. Lei, X. Zhang, U. S. Provisional Patent, filed March 30, 2001.
4. “New Chiral Phospholanes for Asymmetric Catalysis” X. Zhang, US Patent filed November 6, 2001.
5. “P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US provisional Patent, November 10, 2001.
6. “Asymmetric Reductive Amination of Ketones” X. Zhang, US Provisional Patent, filed October 25, 2002.
7. “P-chiral Phospholanes and Phosphocyclic compounds and their use in asymmetric catalytic reactions” W. Tang, X. Zhang, US Patent, November 10, 2002.
8. “New Chiral Oxazoline Ligands for Asymmetric Catalysis” D. Liu, X. Zhang, US Provisional Patent, December 17, 2003.
9. “Asymmetric Hydrogenation of Alpla-amino Carbonyl Compounds” X. Zhang, US Provisional Patent, January 10, 2004
10. “Preparation of chiral cyclic amino acids and derivatives” X. Zhang, W. Tang, US Patent 2004242889.
11. “P-Chiral Phospholanes and Phosphocyclic Compounds and their use in Asymmetric Catalytic Reactionss” X. Zhang, W. Tang, US patent 2004229846.
12. “Catalytic Asymmetric Reductive Amination of Ketones Via Transition Metal Complex Catalyst with Chiral Phosphine Ligands” X. Zhang, PCT, 2004, WO 2004058982.
13. “Preparation of Chiral Phosphorus Cyclic Compounds for Transition Metal-Catalyzed Asymmetric Reactions” X. Zhang, US patent, 2004, 2004072680.
14. “A preparation of aminoalcohols via asymmetric hydrogenation of beta-aminocarbonyl compounds” Zhang,
15. Xumu. US 2005159604 A1 20050721 Patent written in English. Application: US 2005-36157 20050114.
16. “New oxazoline ligands for asymmetric catalysis” Zhang, Xumu; Liu, Duan. U.S. Pat. Appl. Publ. (2005), 2005137403 A1 20050623.
17. “Chelating Tetraphosphorus Ligands with 1,1’-biphenyl backbone for transition Metal-catalyzed hydroformylation of Alkenes and Related Reactions” X. Zhang; Y. Yan, PCT Int. Appl. (2007) 2007078859. A2 20070712.
18. 新型三齿膦配体及其在线性氢甲酰化及类似反应中的应用(P). 张绪穆，陈才友. 中国发明专利，CN102875599. 2013-01-16.
获奖与荣誉
Franklin Veatch Graduate Fellowship, 1991, Stanford University
The Camille and Henry Dreyfus Foundation New Faculty Award, 1994
DuPont Young Faculty Award, 1996
Office of Naval Research Young Investigator Award, 1996
The Camille and Henry Dreyfus Foundation Teacher-Scholar Award, 1998
The John Simon Guggenheim Foundation Fellow, 2000
The Outstanding Oversea Chinese Young Scientist B, Chinese Academy of Sciences, 2000
The Penn State Faculty Scholar Medal, 2001
The Young Innovation Award of ChiTec (Chinese High Tech) in Chemistry, 2001
The American Chemical Society Arthur C. Cope Scholar Award, 2002
The SDCA (San Diego Chinese Association) Achievement Award, 2002
Guest Professor of Shanghai Institute of Organic Chemistry
Guest Professor of Dalian Institute of Chemical Physics
Guest Professor of Wuhan University
2008年， 苏州工业园区第二届科技领军人才
2008年， “江苏省高层次创新创业人才引进计划”引进人才;
2009年， 姑苏创新创业领军人才;
2011年, 获2010年度“中国经济十大创新人物”。